How does #PTSD affect older Veterans? owl.li/ZVf0x
How does #PTSD affect older Veterans? owl.li/ZVf0x
Real Care for Wounded Warriors Foundation Inc.
How does #PTSD affect older Veterans? owl.li/ZVf0x
How does #PTSD affect older Veterans? owl.li/ZVf0x
How does #PTSD affect older Veterans? owl.li/ZVf0x
How does #PTSD affect older Veterans? owl.li/ZVf0x
Natural ways to combat #depression — ow.ly/ZjnlT — #mentalhealth #mindbody #wellness #primarycare
Natural ways to combat #depression — ow.ly/ZjnlT — #mentalhealth #mindbody #wellness #primarycare
#Yogic #breathing shows promise in reducing symptoms of #PTSD #yoga: ow.ly/OXbz8
#Yogic #breathing shows promise in reducing symptoms of #PTSD #yoga: ow.ly/OXbz8
PTSD Treatment and Couples Therapy Go Hand in Hand http://bit.ly/1Uh6nME
PTSD Treatment and Couples Therapy Go Hand in Hand http://bit.ly/1Uh6nME
Mice Study Suggests Link between Gut Bacteria and Risk of PTSD, Mood Disorders
New research suggests intestinal bacteria can influence the way the brain responds to stressful situations.
Dr. John Bienenstock and Dr. Paul Forsythe — who work in the Brain-Body Institute at McMaster University in Ontario, Canada believe gut bacteria could be used to cure or prevent neurological conditions such as post-traumatic stress disorder (PTSD), anxiety and depression.
The study is sponsored by the Office of Naval research (ONR).
“This is extremely important work for U.S. warfighters because it suggests that gut microbes play a strong role in the body’s response to stressful situations, as well as in who might be susceptible to conditions like PTSD,” said Dr. Linda Chrisey, a program officer in ONR’s Warfighter Performance Department.
Researchers explain that the trillions of microbes in the intestinal tract, collectively known as the gut microbiome, profoundly impact human biology. The bacteria play an active role in digesting food, regulating the immune system and even transmitting signals to the brain that alter mood and behavior.
ONR believes the research will increase warfighters’ mental and physical resilience in situations involving dietary changes, sleep loss, or disrupted circadian rhythms (from shifting time zones or living in submarines).
Through research on laboratory mice, Bienenstock and Forsythe have shown that gut bacteria seriously affect mood and demeanor. They also were able to control the moods of anxious mice by feeding them healthy microbes from fecal material collected from calm mice.
Bienenstock and Forsythe used a “social defeat” scenario in which smaller mice were exposed to larger, more aggressive ones for a couple of minutes daily for 10 consecutive days.
The smaller mice showed signs of heightened anxiety and stress — nervous shaking, diminished appetite, and less social interaction with other mice. The researchers then collected fecal samples from the stressed mice and compared them to those from calm mice.
“What we found was an imbalance in the gut microbiota of the stressed mice,” said Forsythe.
“There was less diversity in the types of bacteria present. The gut and bowels are a very complex ecology. The less diversity, the greater disruption to the body.”
Bienenstock and Forsythe then fed the stressed mice the same probiotics (live bacteria) found in the calm mice and examined the new fecal samples. Through magnetic resonance spectroscopy (MRS), a non-invasive analytical technique using powerful MRI technology, they also studied changes in brain chemistry.
“Not only did the behavior of the mice improve dramatically with the probiotic treatment,” said Bienenstock, “but it continued to get better for several weeks afterward. Also, the MRS technology enabled us to see certain chemical biomarkers in the brain when the mice were stressed and when they were taking the probiotics.”
The biomarkers may be a key to detecting risk and suggesting proactive therapy.
Both researchers said stress biomarkers could potentially indicate if someone is suffering from PTSD or risks developing it, allowing for treatment or prevention with probiotics and antibiotics.
Later this year, Bienenstock and Forsythe hope to secure funding to conduct clinical trials to administer probiotics to human volunteers and use MRS to monitor brain reactions to different stress levels.
ONR explains that the analysis of gut microbiology is part of a program in warfighter performance. Researchers are also looking at the use of synthetic biology to enhance the gut microbiome.
Synthetic biology creates or re-engineers microbes or other organisms to perform specific tasks like improving health and physical performance. The field was identified as a top ONR priority because of its potential far-ranging impact on warfighter performance and fleet capabilities.
Source: ONR
Human anatomy focusing on stomach photo by shutterstock.
Accuracy of screening for posttraumatic stress disorder in specialty mental health clinics in the U.S. Veterans Affairs Healthcare System.
Accuracy of screening for posttraumatic stress disorder in specialty mental health clinics in the U.S. Veterans Affairs Healthcare System.
Psychiatry Res. 2016 Apr 21;240:157-162
Authors: Tsai J, Pietrzak RH, Hoff RA, Harpaz-Rotem I
Abstract
This study 1) describes the prevalence of positive PTSD screens among male, female, and OEF/OIF/OND veterans using various PTSD Checklist-Military version (PCL-M) criteria; 2) evaluates the sensitivity and specificity of various PCL-M criteria; and 3) identifies optimal screening criteria in predicting clinician-documented PTSD diagnoses. VA electronic medical records data from 327,093 veterans during 2008-2012 were analyzed. Receiver operating characteristic curve analyses compared PCL-M scores against clinician-documented PTSD diagnoses. Results showed that different PCL-M scoring criteria resulted in 62.0-84.5% of veterans screening positive for PTSD compared to 40.1% with a clinician-documented PTSD diagnosis. Sensitivity of the PCL-M ranged from 73.7 to 93.5% and specificity ranged from 21.6 to 45.8% for all veterans. The optimal PCL-M cut score according to Youden’s index was ≥45 for male veterans, ≥35 for female veterans, and ≥38 for OEF/OIF/OND veterans. Self-report measures like the PCL-M may be a useful screening tool for identifying probable PTSD in VA specialty clinics, but they should be calibrated for different veteran subgroups and followed by structured clinical interviews.
PMID: 27107669 [PubMed – as supplied by publisher]
Belonging protects against postdeployment depression in military personnel.
Related Articles |
Belonging protects against postdeployment depression in military personnel.
Depress Anxiety. 2015 May;32(5):349-55
Authors: Bryan CJ, Heron EA
Abstract
BACKGROUND: Depression among U.S. military personnel has received relatively little empirical attention compared to posttraumatic stress disorder, despite evidence that depression is associated with poor psychosocial outcomes and increased suicide risk. Even less is known about factors that protect against depression in military populations.
METHODS: A sample of 168 active duty Air Force convoy operators completed self-report measures of depression, posttraumatic stress, and sense of “belonging” before deploying to Iraq, and again at 1, 3, 6, and 12 months following their return. Linear growth modeling was used to test the associations of the variables over time.
RESULTS: Mean depression scores remained low and stable across the deployment and 12-month follow-up period. Increased depression severity was significantly associated with low belonging (P < .001) and with posttraumatic stress symptoms (P < .001) at every time point.
LIMITATIONS: Relatively small, predominantly male sample utilizing self-report methods.
CONCLUSIONS: A sense of belongingness may protect service members from depression at all stages of the deployment cycle, from predeployment preparations through deployment and postdeployment adjustment.
PMID: 25903038 [PubMed – indexed for MEDLINE]